Molecular Medicine publishes original research articles and expert commentaries on emerging concepts in the interdisciplinary field of molecular medicine. Considered the vanguard of the new millennium in which science truly complements the art of medicine, Molecular Medicine strives to understand the molecules key to normal body functioning and the pathogenesis of disease, and based on that knowledge, to design specific molecular tools for diagnosis, treatment and prevention. A nonprofit journal organized and peer-reviewed by expert scientists and editors, Molecular Medicine is committed to: • providing a venue where rigor and scholarship reign, • promoting and advancing scientific discourse, and • imparting a common language and understanding among diverse clinical groups, from allergists to virologists and everyone in between. Like the field, Molecular Medicine the journal continues to grow as it scales the heights of modern biomedical science. It has captured the imagination of many of the best basic science and clinical investigators. Pick up an issue today and see for yourself! http://www.molmed.org Science & Medicine 2008 Molecular Medicine Wed, 03 Mar 2010 10:13:00 -0500 mpuerta@NSHS.edu Mon, 01 Mar 2010 10:34:23 -0500 kstroud@optonline.net FeedForAll Mac v2.1 (2.1.0.2); http://www.FeedForAll.com/ http://www.molmed.org/images/MolMedCover1_2_10.jpg http://www.molmed.org Insight into the Cellular and Molecular Basis of Disease 108 140 Understanding RNA processing and surveillance mechanisms is essential to advancing clinical diagnosis and therapeutic procedures. Numerous diseases are caused by errors and mutations of significant RNA sequences leading to the expression of pathological proteins. Recent studies have elucidated our understanding of molecular mechanisms of mRNA processing and the complex series of events that lead to loss or gain of both functional and deleterious proteins. In this review, Dr. Moraes discusses mRNA quality control mechanisms and their clinical relevance to developing therapeutic strategies. http://www.molmed.org/content/2010/1-2-10/09_26_Moraes.pdf 6D4B89D4-916C-11DC-909A-0014510BD93E-17496-0000048FE4895858-FFA Mon, 01 Mar 2010 10:30:47 -0500 Acute respiratory distress syndrome (ARDS), a central cause of morbidity and mortality in intensive care units, is caused by an uncontrolled systemic inflammatory response to such conditions as sepsis, major surgery, and trauma. Innate immunity can be triggered through pattern recognition receptors (PRRs), which recognize conserved microbial motifs or pathogen associated molecular patterns (PAMPs) and endogenous danger signals. The activation of PRRs initiates extracellular as well as intracellular signaling cascades that ultimately promote inflammatory responses. Drs. Xiang and Fan focus on recent advances on the role of PRRs in the mechanisms of ARDS. A greater understanding of these complex pathways is necessary to explore new treatment options for ARDS patients. http://www.molmed.org/content/2010/1-2-10/09_97_Xiang.pdf CD9B8AE6-A9BA-11DD-860A-0014510BD93E-733-0000002C57448DCD-FFA Mon, 01 Mar 2010 10:31:34 -0500 http://www.molmed.org/content/2010/1_2_10.htm F4FE4178-B947-11DC-AB6F-0014510BD93E-5990-0000015FEE23FAC9-FFA Mon, 01 Mar 2010 10:32:22 -0500 GTS-21 Attenuates Cytokine Production In Human Whole Blood And Human Monocytes TPC: Non-erythropoietic Tissue Protective Compound ... more     http://www.molmed.org E83EBF4E-8701-11DC-B50B-0014510BD93E-3049-0000012299B8F2DB-FFA Mon, 27 Apr 2009 10:52:39 -0400